The adaptive growth and mechanisms of <i>Klebsiella pneumoniae</i> under sucrose and glucose exposure
This work elucidates the impact of single-carbon source gradients and sustained sugar induction on the adaptive growth and drug resistance of <i>Klebsiella pneumoniae</i> and preliminarily reveals the roles of <i>scrA</i> and <i>scrY</i> in carbohydrate metabolism, suggesting a possible mechanism by which sucrose and glucose affect the adaptive growth of <i>K. pneumoniae</i>. These findings contribute to the theoretical understanding of CCR and provide insights that may inform clinical management of <i>K. pneumoniae</i>-related infections.
Authors
- Duoyun Li
- Kewei Fan (ORCID: https://orcid.org/0009-0007-3412-5572)
- Zhijian Yu (ORCID: https://orcid.org/0000-0002-5677-2064)
- Zewen Wen (ORCID: https://orcid.org/0000-0002-9934-2056)
- Congcong Li (ORCID: https://orcid.org/0000-0002-4459-5224)
- Yong He (ORCID: https://orcid.org/0000-0001-6752-1757)
- Fangfang Liu (ORCID: https://orcid.org/0000-0002-9527-1131)
- Tieying Hou (ORCID: https://orcid.org/0000-0002-3902-2632)
- Jiayan Wu (ORCID: https://orcid.org/0000-0001-6048-405X)
Institutions
- Shenzhen University (CN)
- University Town of Shenzhen (CN)
- Shenzhen Sixth People's Hospital (CN)
- Shenzhen University Health Science Center (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1128/spectrum.01603-25
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00