Whole-Genome Sequencing Reveals a Novel GATA2 Mutation in Lower-Grade Glioma: Bioinformatics Analysis of Functional and Therapeutic Implications
Our preliminary findings suggest a potential role of the <i>GATA2</i> p.Arg396Trp mutation in lower-grade glioma pathogenesis. The mutation predicted impact on transcriptional regulation and drug affinity suggests <i>GATA2</i> as a possible biomarker candidate. Extensive experimental validation in larger patient cohorts is needed to establish clinical relevance and explore targeted therapeutic strategies.
Authors
- Didik Setyo Heriyanto (ORCID: https://orcid.org/0000-0001-9728-5046)
- Renindra Ananda Aman (ORCID: https://orcid.org/0000-0002-5135-6256)
- Soehartati Gondhowiardjo (ORCID: https://orcid.org/0000-0002-9446-4361)
- Handoko Handoko
- Eka Susanto
- Vincent Lau (ORCID: https://orcid.org/0000-0003-4698-7501)
Institutions
- Universitas Gadjah Mada (ID)
- University of Indonesia (ID)
- Precision for Medicine (United States) (US)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Rumah Sakit Umum Pusat Dr. Sardjito (ID)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3390/cancers17203338
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00