Mortality Among Patients With Invasive Group A Streptococcal Infections Caused by the M1UK Lineage: A Retrospective Cohort Study in England and Wales
Mortality did not differ significantly between M1UK and M1global lineages, but more studies are required. Overall mortality from emm1 S. pyogenes remains strikingly high. The rapid time to death underscores the need for preventive measures and rapid diagnostic tools that act prior to culture-based confirmation, and highlights challenges for clinical trial design in iGAS.
Authors
- Rebecca Guy (ORCID: https://orcid.org/0000-0001-5500-5691)
- Shiranee Sriskandan (ORCID: https://orcid.org/0000-0002-5214-4941)
- Juliana Coelho (ORCID: https://orcid.org/0000-0002-4514-3449)
- Nina Zhu (ORCID: https://orcid.org/0000-0001-6822-2708)
- Ho Kwong Li (ORCID: https://orcid.org/0000-0002-8149-5943)
- Roger Daniel (ORCID: https://orcid.org/0000-0002-8836-4874)
- Theresa Lamagni (ORCID: https://orcid.org/0000-0002-3965-8323)
- Olivia Waddell
Institutions
- Department of Health and Social Care (GB)
- Technology Focus (United States) (US)
- NIHR Imperial Biomedical Research Centre (GB)
- UK Health Security Agency (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1093/cid/ciaf492
- Citations
- 1
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.88