Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma
The pancreatobiliary signature and BVI constitute critical high-risk pathologic features in AAC. TD status identified high-risk cohorts, thus enabling postoperative risk-stratified treatment strategies. In patients negative for pancreatobiliary signature or BVI, TD positivity predicted significantly worse survival.
Authors
- Chenyang Meng
- Xuejing Shi
- Yukuan Feng (ORCID: https://orcid.org/0009-0005-6497-0748)
- Song Gao
- Jun Yu (ORCID: https://orcid.org/0000-0003-3435-6550)
- Weidong Ma (ORCID: https://orcid.org/0000-0001-9039-1858)
- Xiuchao Wang (ORCID: https://orcid.org/0000-0002-3205-8544)
- Zhaoyu Zhang
- Shangheng Shi (ORCID: https://orcid.org/0009-0006-2888-476X)
- Jihui Hao (ORCID: https://orcid.org/0000-0002-1607-1730)
- Yuexiang Liang (ORCID: https://orcid.org/0000-0002-5201-8187)
- Xingyun Chen (ORCID: https://orcid.org/0000-0001-7699-4425)
- Wei Li (ORCID: https://orcid.org/0000-0003-2894-6263)
- Hongwei Wang (ORCID: https://orcid.org/0000-0003-3581-8892)
- Jian Wang (ORCID: https://orcid.org/0000-0002-1278-256X)
- Shuo Li (ORCID: https://orcid.org/0000-0001-6530-0424)
- Qiuli Li (ORCID: https://orcid.org/0000-0001-5648-4970)
- Xiaoqing Ma (ORCID: https://orcid.org/0000-0003-1626-7300)
- Tianxing Zhou (ORCID: https://orcid.org/0009-0006-0150-1343)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2025-10-16
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0181
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China