Evidence of fructose metabolism in colorectal cancer
Colorectal cancer (CRC) represents a significant global health burden, contributing significantly to cancer-related mortality. The underlying genetic and metabolic underpinnings of CRC remain incompletely understood. In this study, we conducted a comprehensive investigation into metabolic perturbations in 29 CRC patients utilizing targeted omics approaches, compared to public databases. Additionally, we examined serum and tissue samples from 12 patients, with and without preoperative glucose challenge, using targeted metabolomics to investigate glucose and fructose metabolism. Notably, elevated levels of serum D-Fructose and L-Lactic acid following glucose administration indicate augmented glycolytic activity and polyol pathway-mediated glucose conversion (to fructose). Despite variations in tumor responses, our results underscore the potential significance of fructose metabolism in CRC progression, shedding light on therapeutic avenues targeting the Warburg effect. This research lays a solid foundation for future translational research into metabolic interventions in CRC treatment and enhances our understanding of cancer-related metabolic reprogramming.
Authors
- Giuseppe Sica (ORCID: https://orcid.org/0000-0002-7407-0584)
- Luca Savino (ORCID: https://orcid.org/0000-0001-9068-2225)
- Francesca Servadei (ORCID: https://orcid.org/0000-0003-2619-9153)
- Gerry Melino (ORCID: https://orcid.org/0000-0001-9428-5972)
- Hartmut Juhl (ORCID: https://orcid.org/0000-0001-7373-6703)
- Julia Bischof (ORCID: https://orcid.org/0000-0002-6672-6571)
- Manuel Scimeca (ORCID: https://orcid.org/0000-0003-0585-1309)
- Lukas Funke (ORCID: https://orcid.org/0000-0002-4913-1912)
- Wen‐Lian Chen (ORCID: https://orcid.org/0000-0002-1359-2549)
- Eleonora Candi (ORCID: https://orcid.org/0000-0001-8332-4825)
- Alessandro Mauriello (ORCID: https://orcid.org/0000-0002-7351-5676)
- Runying Yang (ORCID: https://orcid.org/0000-0002-5983-9439)
- Lu Wang (ORCID: https://orcid.org/0000-0002-3918-3399)
- Wei Jia (ORCID: https://orcid.org/0000-0002-3739-8994)
- Qiang Sun (ORCID: https://orcid.org/0000-0002-5342-0637)
- Xinyue Gao
- Qing Zhao
Institutions
- University of Rome Tor Vergata (IT)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Hong Kong Virtual University (CN)
- Biotechnology Research Institute (CA)
- Shanghai Sixth People's Hospital (CN)
- Dermatologikum Hamburg (DE)
- University of Hong Kong (HK)
Publication Details
- Journal
- Cell Death Discovery
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1038/s41420-025-02745-w
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- National Natural Science Foundation of China
- Associazione Italiana per la Ricerca sul Cancro