Single-distance, phase-only frequency-domain NIRS for vascular oxygenation and tissue metabolism: a Monte Carlo simulation study
These results validate single-separation phase-only FD-NIRS as an accurate method for multichromophore quantification (including <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow><mml:msub><mml:mi>CCO</mml:mi> <mml:mtext>redox</mml:mtext></mml:msub> </mml:mrow> </mml:math> ), enabling simpler, cost-effective systems without compromising metabolic imaging capability. The approach achieves <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mo><</mml:mo> <mml:mn>10</mml:mn> <mml:mo>%</mml:mo></mml:mrow> </mml:math> error in hemoglobin quantification while eliminating traditional multidistance requirements.
Authors
- Haiyang Tang (ORCID: https://orcid.org/0000-0001-9537-2891)
- Miles F. Bartlett (ORCID: https://orcid.org/0000-0001-7293-4214)
- Michael D. Nelson (ORCID: https://orcid.org/0000-0002-3232-8639)
- Hanli Liu (ORCID: https://orcid.org/0000-0002-9312-5691)
- Yiqing Hu (ORCID: https://orcid.org/0009-0000-0342-0834)
- Muaaz Faiyazuddin
Institutions
- The University of Texas at Arlington (US)
- Bartlett Public Library District (US)
Publication Details
- Journal
- Journal of Biomedical Optics
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1117/1.jbo.30.s3.s34113
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging