Immunization with VLP-based vaccines induces high IgG antibody titers in dermal interstitial fluid

Although antibodies often exert their effects within the interstitium, the distribution of antibodies within extravascular tissue compartments is not typically measured. Here, IgG titers in peripheral blood and dermal interstitial fluid (ISF) were compared after intramuscular and intradermal immunization with virus-like particle (VLP)-based vaccines. Antibody titers and durability in serum and ISF were similar, indicating that VLP-based vaccines can efficiently elicit strong antibody responses in the skin.