First-in-Human PET Imaging of MT1-MMP in a Patient with Breast and Muscle-Invasive Urothelial Bladder Cancer Using the Bicyclic Radiotracer [<sup>68</sup>Ga]Ga-BCY25286
Membrane type 1 matrix metalloproteinase (MT1-MMP) is overexpressed in various solid tumors, contributing to tumor invasion, metastasis, and poor prognosis ([1][1]). To date, a clinical translation has not yet been accomplished ([2][2]). Here, we report the first-in-human clinical translation of MT1
Authors
- Michael Mix (ORCID: https://orcid.org/0000-0002-9106-2519)
- Ann-Christin Eder (ORCID: https://orcid.org/0000-0002-5858-469X)
- Matthias Eder (ORCID: https://orcid.org/0000-0002-5110-0744)
- Philipp T. Meyer (ORCID: https://orcid.org/0000-0001-8336-750X)
- Mohamed El Fakiri (ORCID: https://orcid.org/0000-0003-2997-6835)
- Cornelius F. Waller (ORCID: https://orcid.org/0000-0002-5777-0212)
- Cordula A. Jilg (ORCID: https://orcid.org/0000-0001-5823-5679)
- Christoph Schell (ORCID: https://orcid.org/0000-0001-5344-624X)
- Martin T. Freitag (ORCID: https://orcid.org/0000-0002-2116-6873)
- Mohamed Aymen Omrane
- Christoph‐Ferdinand Wielenberg
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
Publication Details
- Journal
- Journal of Nuclear Medicine
- Published
- 2025-10-16
- DOI
- https://doi.org/10.2967/jnumed.125.269882
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00