Low microRNA-338-3p expression drives cutaneous squamous cell carcinoma progression and predicts poor prognosis

Abstract Objectives To explore the clinical significance and influence of miR-338-3p in cSCC. Methods The content of miR-338-3p in cSCC was quantified using qRT-PCR. Prognostic relevance of miR-338-3p in cSCC was evaluated via Kaplan-Meier curve analysis. Functional roles of miR-338-3p in cSCC cell behavior were assessed through MTT assays, transwell assays. Results miR-338-3p was low-expressed in cSCC, with levels linked with lymph node metastasis, TNM stage, and disease progression. Statistically, miR-338-3p was a predictor of poor prognosis in cSCC. Functionally, miR-338-3p restoration weakened cSCC cellular viability and metastatic potential in vitro . Conclusions In cSCC, miR-338-3p exhibited downregulated expression, which suppressed cell viability, migratory behaviors, and invasive abilities. It has potential as a predictor for prognosis and a therapeutic target in cSCC.