Guidelines for Next-Generation Sequencing in Sarcoma Diagnosis and Treatment
Evidence supporting the routine, nonselective use of NGS in patients with sarcoma is currently limited. Given the complexity, the decision to perform an NGS panel, as well as the interpretation and use of its results for diagnostic or therapeutic purposes, should take place only in sarcoma-expert institutions, including a multidisciplinary review. The results of multigene panels performed in nonexpert sarcoma centers cannot replace the pathology review or the recommendation of NGS-guided therapies without prior evaluation by sarcoma experts.
Authors
- Andrea Napolitano (ORCID: https://orcid.org/0000-0002-7509-1555)
- Claudia Valverde (ORCID: https://orcid.org/0000-0003-4107-8616)
- Carlo María Cicala (ORCID: https://orcid.org/0000-0002-4350-495X)
- Javier Martín‐Broto (ORCID: https://orcid.org/0000-0001-7350-6916)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Hans A. J. Gelderblom (ORCID: https://orcid.org/0000-0001-9270-8636)
- Paolo G. Casali (ORCID: https://orcid.org/0000-0003-4056-8023)
- William D. Tap (ORCID: https://orcid.org/0000-0001-7779-2796)
- Jean‐Yves Blay (ORCID: https://orcid.org/0000-0001-7190-120X)
- Anastasios Kyriazoglou (ORCID: https://orcid.org/0000-0003-3222-4060)
- Khin Thway (ORCID: https://orcid.org/0000-0001-9727-8030)
- Robin L. Jones (ORCID: https://orcid.org/0000-0003-4173-3844)
- Eva Wardelmann (ORCID: https://orcid.org/0000-0001-6788-4910)
- César Serrano (ORCID: https://orcid.org/0000-0003-1416-8739)
- Winette T.A. van der Graaf (ORCID: https://orcid.org/0000-0001-7549-3338)
- François Le Loarer (ORCID: https://orcid.org/0000-0001-8582-9819)
- David J. Thomas (ORCID: https://orcid.org/0000-0003-3374-7648)
- Silvia Stacchiotti (ORCID: https://orcid.org/0000-0002-1742-8666)
- Piotr Rutkowski (ORCID: https://orcid.org/0000-0002-8920-5429)
- Bernd Kasper (ORCID: https://orcid.org/0000-0001-8425-8356)
- Judith V.M.G. Bovée (ORCID: https://orcid.org/0000-0003-1155-0481)
- Antonia Digklia (ORCID: https://orcid.org/0000-0001-7189-3035)
- Sebastian Bauer (ORCID: https://orcid.org/0000-0003-4544-0504)
- Antoine Italiano
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Royal Marsden NHS Foundation Trust (GB)
- Memorial Sloan Kettering Cancer Center (US)
- Garvan Institute of Medical Research (AU)
- University of Padua (IT)
- Université de Bordeaux (FR)
- University of Milan (IT)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University Hospital Heidelberg (DE)
- The Netherlands Cancer Institute (NL)
- UNSW Sydney (AU)
- University Hospital Münster (DE)
- Centre Léon Bérard (FR)
- Essen University Hospital (DE)
- Royal Marsden Hospital (GB)
- Vall d'Hebron Hospital Universitari (ES)
- Institut Bergonié (FR)
- University General Hospital Attikon (GR)
- Erasmus MC Cancer Institute (NL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- University Medical Centre Mannheim (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Vall d'Hebron Institute of Oncology (ES)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- European Institute of Oncology (IT)
- University of Lausanne (CH)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1001/jamaoncol.2025.3608
- Citations
- 5
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.59