Symptoms but Not Physiology Differentiate Functional Dyspepsia With or Without Overlapping Gastrointestinal Disorders
The common overlap between FD, IBS, and reflux is characterized by a high GI-specific, psychological, and somatic symptom burden. By contrast, key pathophysiological parameters were not different between FD with and without overlapping disorders or between FD subtypes. Central integration of multiple GI manifestations rather than more severely impaired peripheral alterations is more likely to explain the high symptom burden in overlapping disorders.
Authors
- Lukas Van Oudenhove (ORCID: https://orcid.org/0000-0002-6540-3113)
- Karen Van den Houte (ORCID: https://orcid.org/0000-0003-4910-4639)
- Lukas Michaja Balsiger (ORCID: https://orcid.org/0000-0001-7399-8500)
- Jan F. Tack (ORCID: https://orcid.org/0000-0002-3206-6704)
- Cedric Van de Bruaene (ORCID: https://orcid.org/0000-0002-7823-016X)
- Bert Broeders (ORCID: https://orcid.org/0000-0001-6050-8461)
- Lucas Wauters (ORCID: https://orcid.org/0000-0002-3195-4996)
- Tim Vanuytsel (ORCID: https://orcid.org/0000-0001-8728-0903)
- Jolien Schol (ORCID: https://orcid.org/0000-0003-0537-969X)
- Matthias Ceulemans (ORCID: https://orcid.org/0000-0002-9951-5383)
Institutions
- Science Health Allied Research Education (IN)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical and Translational Gastroenterology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.14309/ctg.0000000000000938
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Danone
- Novartis Foundation
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Novartis Stiftung für Medizinisch-Biologische Forschung
- Vlaamse regering
- Bijzonder Onderzoeksfonds UGent