Plasmacytoid dendritic cells modulate the production of mucosal IgA in IgA nephropathy
Mucosal pDCs contribute to the pathogenesis of IgAN by facilitating the production of aberrantly glycosylated IgA via TLR9 signaling. Our findings demonstrated that pDC may be a novel therapeutic target for IgAN.
Authors
- Masao Kihara
- Hitoshi Suzuki (ORCID: https://orcid.org/0000-0002-1901-2111)
- Yoshihito Nihei (ORCID: https://orcid.org/0000-0002-0345-0192)
- Mingfeng Lee (ORCID: https://orcid.org/0000-0001-6198-0856)
- Yuko Makita (ORCID: https://orcid.org/0000-0001-5745-6007)
- Maiko Nakayama (ORCID: https://orcid.org/0000-0002-2818-5081)
- Yusuke Fukao (ORCID: https://orcid.org/0000-0003-3846-8234)
- Rina Kato
- Yusuke Suzuki (ORCID: https://orcid.org/0000-0003-2234-3023)
- Toshiki Kano
Institutions
- University of Toronto (CA)
- Juntendo University (JP)
- Juntendo University Urayasu Hospital (JP)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/ndt/gfaf216
- Citations
- 2
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Japan Society for the Promotion of Science