Impact of Wilms’ tumor 1 gene (WT1) mutation on outcome of allogeneic hematopoietic-cell transplantation for acute myeloid leukemia: a retrospective multicenter cohort study from the ALWP/EBMT registry
We compared transplantation outcomes of AML patients with WT1 mutation (mWT1), identified by next-generation sequencing, to those of patients with wild-type WT1 AML (wtWT1). 703 patients were included, 50 with mWT1 and 653 with wtWT1. Patients with mWT1 were younger (median age: 45.6 vs. 56.4 years, p < 0.001), with a higher proportion of females (66% vs. 47.6%, p = 0.01), higher frequency of mutations in FLT3-ITD (38.3% vs. 21.7%, p = 0.01) and CEBPA (15.8% vs. 5.7%, p = 0.03). Donors were matched siblings in 30.6%, unrelated in 45.6%, and haploidentical in 22.1%. A higher percentage of mWT1 vs. wtWT1 patients received in vivo T-cell depletion (66% vs. 51%, p = 0.03) and 58% vs. 47.1% received myeloablative conditioning. 49 patients with mWT1 were matched to 127 wtWT1 patients in matched-pairs analysis. Outcomes (mWT1 vs. wtWT1) were not significantly different: relapse (2 y: 28.8% vs. 30.4%, HR: 1.14, p = 0.64), NRM (2 y: 15.5% vs. 9.9%, HR: 1.41, p = 0.49), LFS (2 y: 55.7% vs. 59.6%, HR: 1.21, p = 0.39), OS (2 y: 65.4% vs. 73.3%, p = 0.66), and chronic GVHD (2 y:24.3% vs. 25.4%, p = 0.95). In conclusion, WT1 mutation did not influence transplantation outcomes of AML patients in CR1.
Authors
- Ann De Becker (ORCID: https://orcid.org/0000-0003-0947-8708)
- Pavel Jindra (ORCID: https://orcid.org/0000-0002-8415-7069)
- Éolia Brissot (ORCID: https://orcid.org/0000-0003-4471-418X)
- Jordi Esteve (ORCID: https://orcid.org/0000-0002-8056-648X)
- Mohamad Mohty (ORCID: https://orcid.org/0000-0002-7264-808X)
- Matthew Collin (ORCID: https://orcid.org/0000-0002-2820-8706)
- Ain Kaare (ORCID: https://orcid.org/0000-0002-3170-1016)
- Fabio Ciceri (ORCID: https://orcid.org/0000-0003-0873-0123)
- Ali Bazarbachi (ORCID: https://orcid.org/0000-0002-7171-4997)
- Jaime Sanz (ORCID: https://orcid.org/0000-0001-6934-4619)
- Xavier Poiré (ORCID: https://orcid.org/0000-0003-1897-0227)
- Maija Itälä‐Remes (ORCID: https://orcid.org/0000-0001-5844-1632)
- Patrizia Chiusolo (ORCID: https://orcid.org/0000-0002-1355-1587)
- Arnon Nagler (ORCID: https://orcid.org/0000-0002-0763-1265)
- Khalid Halahleh (ORCID: https://orcid.org/0000-0002-1161-9138)
- Jacques‐Emmanuel Galimard (ORCID: https://orcid.org/0000-0001-9102-4427)
- Laimonas Griškevičius (ORCID: https://orcid.org/0000-0002-3731-1537)
- Johan A. Maertens (ORCID: https://orcid.org/0000-0003-4257-5980)
- Josè Antonio Pérez-Simón (ORCID: https://orcid.org/0000-0003-3616-6101)
- He Huang
- María Jesús Pascual Cascón
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Cliniques Universitaires Saint-Luc (BE)
- Inserm (FR)
- Charles University (CZ)
- King Hussein Cancer Center (JO)
- Sheba Medical Center (IL)
- Universitair Ziekenhuis Leuven (BE)
- Royal Victoria Infirmary (GB)
- Turku University Hospital (FI)
- Tartu University Hospital (EE)
- Agostino Gemelli University Polyclinic (IT)
- Hospital Universitari i Politècnic La Fe (ES)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- American University of Beirut Medical Center (LB)
- Hospital Regional Universitario de Málaga (ES)
- Universitair Ziekenhuis Brussel (BE)
- IRCCS Ospedale San Raffaele (IT)
- Centre de Recherche Saint-Antoine (FR)
- Hospital Universitario Virgen del Rocío (ES)
- Vilnius University Hospital Santariskiu Klinikos (LT)
- European Society for Blood and Marrow Transplantation (FR)
- First Affiliated Hospital Zhejiang University (CN)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Bone Marrow Transplantation
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1038/s41409-025-02727-7
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77