STAT3 and STAT6 activation in lung tissues correlates with inflammatory and clinical traits in COPD
<b>The study highlights the role of JAK/STAT signalling in COPD, with STAT3 linked to neutrophilic inflammation and STAT6 to eosinophilic inflammation and chronic bronchitis. Findings support targeted therapies to address specific clinical traits in COPD.</b> https://bit.ly/4qoEs0h.
Authors
- Debora Fragni
- Daniela Miglietta
- Simonetta Baraldo (ORCID: https://orcid.org/0000-0001-8923-7511)
- Marco Contoli (ORCID: https://orcid.org/0000-0002-2731-5809)
- Paolo Casolari (ORCID: https://orcid.org/0000-0002-7848-1217)
- Alberto Papi (ORCID: https://orcid.org/0000-0002-6924-4500)
- Elisa Schiavi
- Umberto Semenzato (ORCID: https://orcid.org/0000-0002-6739-8629)
- Federico Baraldi (ORCID: https://orcid.org/0009-0007-5649-8409)
Institutions
- University of Padua (IT)
- University of Ferrara (IT)
- Azienda Unità Sanitaria Locale di Ferrara (IT)
- Arcispedale Sant'Anna (IT)
- Chiesi Foundation (IT)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1183/23120541.01310-2025
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00