Petunidin alleviates diabetic nephropathy injury via the inhibition of oxidative stress and ferroptosis through the Keap1/mitoNQO1 pathway
Keap1 expression in the kidneys of db/db mice was significantly increased, along with reduced mitochondrial translocation of NQO1, while PET reversed this trend to decrease oxidative stress and inhibit ferroptosis. Further experiments confirmed that after overexpression of Keap1, the protective effect of PET in high glucose-induced HK2 cells disappeared, whereas overexpression of mitoNQO1 reduced oxidative stress and ferroptosis in a mitochondria-dependent way.
Authors
- Gang Wu (ORCID: https://orcid.org/0000-0001-6558-3508)
- Y. Qiu (ORCID: https://orcid.org/0000-0002-1117-0617)
- Xinyan Li (ORCID: https://orcid.org/0000-0003-2489-4312)
- Wenjun Mao
- Xiaoqin Zou (ORCID: https://orcid.org/0000-0003-0637-8648)
- Yih‐Leong Chang (ORCID: https://orcid.org/0000-0001-5309-0554)
- Chao Chen (ORCID: https://orcid.org/0000-0002-4422-1716)
- Yan Xiao-pei
- Su Li (ORCID: https://orcid.org/0000-0001-6225-2842)
- Yuqiong Chen (ORCID: https://orcid.org/0000-0001-7592-5989)
Institutions
- Sun Yat-sen University (CN)
- Nantong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Suzhou Municipal Hospital (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Northern Jiangsu People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fcell.2025.1651382
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00