Exploring Endovascular Photo-Activated Ablation (EPA) for Downstaging Locally Advanced Pancreatic Cancer: A Proof-of-Concept Study in the Normal Porcine Model
These proof-of-concept results demonstrate that EPA can produce pancreatic perivascular necrosis in a large animal model. In a pancreatic cancer abutting a major blood vessel, this procedure may be able to create a zone free of viable tumour, potentially rendering these cancers operable, while preserving vessel integrity. These findings support further research activities towards clinical translation.
Authors
- Lothar Lilge (ORCID: https://orcid.org/0000-0001-5533-0005)
- Fanélie Wanert (ORCID: https://orcid.org/0000-0002-8071-2109)
- Alain García Vázquez (ORCID: https://orcid.org/0000-0001-5859-2852)
- Axel Schmid (ORCID: https://orcid.org/0000-0001-6461-8705)
- Tina Saeidi
- Stephen G. Bown (ORCID: https://orcid.org/0000-0002-5538-9303)
- Lee L. Swanström (ORCID: https://orcid.org/0000-0002-1740-463X)
- Juan M. Verde (ORCID: https://orcid.org/0000-0002-9127-8467)
- Arjen Bogaards
- Irene Alexandra Spiridon
Institutions
- University Health Network (CA)
- Radboud University Nijmegen (NL)
- University of Toronto (CA)
- University of Johannesburg (ZA)
- Princess Margaret Cancer Centre (CA)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Universitätsklinikum Erlangen (DE)
- Institut de Chirurgie Guidée par l'Image (FR)
- University College London (GB)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3390/cancers17203340
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00