Perineural Invasion Worsens Long-Term Outcomes of Pancreatic Neuroendocrine Tumors Following Surgical Resection
PNI was an independent adverse prognostic factor among patients undergoing curative-intent resection of pNETs, even among individuals with early-stage disease. The presence of PNI should be routinely assessed and considered in the prognostic stratification of patients following resection of pNETs.
Authors
- Cliff Cho
- Alexandra G. Lopez‐Aguiar (ORCID: https://orcid.org/0000-0002-7928-4901)
- Shishir K. Maithel (ORCID: https://orcid.org/0000-0002-3591-8925)
- Flavio G. Rocha (ORCID: https://orcid.org/0000-0002-6257-5796)
- Yi Lv (ORCID: https://orcid.org/0000-0003-3636-6664)
- Hui Xu (ORCID: https://orcid.org/0000-0001-6441-2512)
- Jingjing Hou (ORCID: https://orcid.org/0000-0001-9984-9386)
- Timothy Michael Pawlik (ORCID: https://orcid.org/0000-0002-7994-9870)
- H. Wéber (ORCID: https://orcid.org/0000-0002-7584-8044)
- George A. Poultsides (ORCID: https://orcid.org/0000-0002-7584-0405)
- Kamran Idrees (ORCID: https://orcid.org/0000-0003-0911-4461)
- Ryan C. Fields (ORCID: https://orcid.org/0000-0001-6176-8943)
- Junxi Xiang (ORCID: https://orcid.org/0000-0002-7772-3261)
- Xu‐Feng Zhang (ORCID: https://orcid.org/0000-0002-4483-7326)
Institutions
- Virginia Mason Medical Center (US)
- University of Wisconsin–Madison (US)
- Emory University (US)
- Vanderbilt University (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- The Ohio State University Wexner Medical Center (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Stanford University (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1245/s10434-025-18561-6
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00