Can ADC changes help mRECIST or LI-RADS treatment response algorithm better diagnose pathological response of HCC after preoperative radiotherapy? Secondary analysis of a prospective phase 2 trial
Precise assessment of hepatocellular carcinoma response is required for patients undergoing preoperative radiotherapy. Radiotherapy induced an increase in ADC values and heightened intratumoral heterogeneity. As the delineated region of interest expanded, AUC decreased and inter-observer agreement increased. Δ-ADC<sub>slice</sub>% exhibited excellent performance in predicting pathological response and the potential to supplement existing evaluation criteria.
Authors
- Shuang Wang (ORCID: https://orcid.org/0000-0001-5037-4316)
- Fan Wu (ORCID: https://orcid.org/0000-0001-7900-7536)
- Bing Feng (ORCID: https://orcid.org/0000-0002-6108-2017)
- Leyao Wang (ORCID: https://orcid.org/0000-0002-2396-9020)
- Xiaohong Ma (ORCID: https://orcid.org/0000-0002-9048-8374)
- Yongjian Zhu (ORCID: https://orcid.org/0000-0002-5924-1998)
- Feng Ye (ORCID: https://orcid.org/0000-0002-5953-6024)
- Bo Chen (ORCID: https://orcid.org/0000-0003-3383-3992)
- Sicong Wang (ORCID: https://orcid.org/0009-0009-6779-5112)
- Zhaowei Chen
- Rong Cong (ORCID: https://orcid.org/0000-0001-7949-3132)
- Li Zhao (ORCID: https://orcid.org/0000-0002-7703-5397)
- Yirui Zhai
Institutions
- General Electric (Spain) (ES)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
Publication Details
- Journal
- Insights into Imaging
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1186/s13244-025-02090-7
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Cancer Foundation of China