Investigating the common genetic basis between inflammatory bowel disease and metabolic syndrome through genomic structural equation modeling
To the best of our knowledge, this study provides the first comprehensive characterization of the shared genetic architecture of IBD and MetS through a multivariate genetic model. The results deepen the understanding of the genetic mechanisms underlying IBD and MetS and offer potential therapeutic targets and a conceptual framework for developing interventions for cross-system diseases.
Authors
- Wei Ge (ORCID: https://orcid.org/0000-0002-4610-7933)
- Pan Shen (ORCID: https://orcid.org/0000-0001-8529-3727)
- Hao Xiong (ORCID: https://orcid.org/0000-0002-7619-4740)
- Wu Liao
- Yifan Ding (ORCID: https://orcid.org/0000-0002-7669-0509)
- Qinghua Luo (ORCID: https://orcid.org/0000-0002-0518-0990)
- L. Zhang
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1371/journal.pone.0334456
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00