Maternal and neonatal outcomes in pregnancies with sFlt-1/PlGF >85: exploring the predictive value of sFlt-1 and PlGF
An sFlt-1/PlGF ratio >85 alone does not necessitate immediate delivery. Our findings suggest two potential overlapping pre-eclampsia phenotypes: high sFlt-1 aligning with maternal vascular dysfunction, and low PlGF indicating predominantly utero-placental disease. These findings support more tailored antenatal surveillance and management strategies based on the individual biomarker profiles, rather than the ratio alone.
Authors
- Talia Rose Hubble (ORCID: https://orcid.org/0000-0002-9043-8318)
- Daniel Stott (ORCID: https://orcid.org/0000-0002-5207-5560)
- David Williams (ORCID: https://orcid.org/0000-0002-8186-9124)
- Stavroula Kastora (ORCID: https://orcid.org/0000-0003-4470-5267)
- Diane Nzelu (ORCID: https://orcid.org/0000-0001-8651-9791)
- Sara L. Hillman (ORCID: https://orcid.org/0000-0003-2971-6865)
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Royal Free London NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- Pregnancy Hypertension
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1016/j.preghy.2025.101266
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00