Targeting MAT2A synergistically induces DNA damage in osteosarcoma cells through EZH2-mediated H3K27me3 modification
This study highlights the potential of integrating metabolic and epigenetic interventions in OS therapy. Our findings might present a promising therapeutic strategy for chemotherapy-resistance OS.
Authors
- Zhuoying Wang (ORCID: https://orcid.org/0000-0002-8121-5286)
- Haoran Mu (ORCID: https://orcid.org/0000-0003-4763-1363)
- Yafei Jiang (ORCID: https://orcid.org/0000-0001-7272-8453)
- Chunxi Yang (ORCID: https://orcid.org/0000-0002-5977-0582)
- Yingqi Hua
- Yining Tao (ORCID: https://orcid.org/0009-0008-4901-3060)
- Zhengdong Cai
- Yang Liu (ORCID: https://orcid.org/0000-0003-4559-5119)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-6147-1573)
- Bing‐Hui Yang (ORCID: https://orcid.org/0009-0004-1516-251X)
- Dongqing Zuo (ORCID: https://orcid.org/0000-0002-6684-9467)
- Xiyu Yang
- Wei Sun (ORCID: https://orcid.org/0000-0002-5310-5661)
- H. Wang (ORCID: https://orcid.org/0009-0001-2467-5331)
Institutions
- Shanghai Mental Health Center (CN)
- Tongren Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1016/j.jot.2025.09.007
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00