Unveiling Endothelial Cell Expression Profiles in <scp>FEVR</scp> : Identification of Key Genes Associated With Pathological Neovascularisation in a <scp> <i>FZD4</i> <sup> <i>M105V</i> </sup> </scp> Mouse Model
We established a novel mouse model of pathological neovascularisation with a missense mutation and elucidated the expression profiles of retinal ECs. The identified pathways and novel biomarkers-particularly CTSS and CCL4-provide new insights for further pathogenesis investigation of FEVR.
Authors
- Rulian Zhao (ORCID: https://orcid.org/0000-0003-3581-3258)
- Huijuan Xu (ORCID: https://orcid.org/0000-0002-1858-1822)
- Yunqi He (ORCID: https://orcid.org/0000-0002-5265-3244)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-2298-500X)
- Xianjun Zhu (ORCID: https://orcid.org/0000-0002-2531-7552)
- Zhenglin Yang (ORCID: https://orcid.org/0000-0003-4519-6759)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- Clinical and Experimental Ophthalmology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1111/ceo.70011
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00