Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial

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Publication Details

Journal
EClinicalMedicine
Published
2025-10-17
DOI
https://doi.org/10.1016/j.eclinm.2025.103556
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
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article

Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial

Hongyun Zhao, Yifan Zhai, Xu Liang, Jinhui Xue et al.
EClinicalMedicine
Lung Cancer Treatments and Mutations
article

Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial

Hongyun Zhao, Yifan Zhai, Xu Liang, Jinhui Xue, Yuanyuan Zhao, Zhengbo Song, Jundong Li, Yanqiu Zhao, Qianwen Liu, Yilan Yang, Dengkun Xiong, Yubiao Guo, Dajun Yang, Jian Fang, Jianhua Chen, Wenfeng Fang, Yang Zhang, Xiaoyan Lin, Yun-Peng Yang, Yu‐Xiang Ma, Gang Wu, Chen Yang, Yan Huang, Yugang Dong, Shaodong Hong, Li Zhang
article en

Abstract

No abstract available for this paper.
EClinicalMedicineVol. 89
Fujian Medical University (CN), Sun Yat-sen University (CN), Peking University (CN), Zhengzhou University (CN), Peking University Cancer Hospital (CN), Zhejiang Cancer Hospital (CN), Hunan Cancer Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Wuhan Union Hospital (CN), Henan Cancer Hospital (CN), Sun Yat-sen University Cancer Center (CN), Bridge Pharma (United States) (US), Union Hospital (CN)
Openalex Percentile: Top 58%
Lung Cancer Treatments and Mutations
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