Active expiration reduces hypercapnia in lung failure – results of the prospective interventional ActiveEx study and development of a prototype device for automated application
Manual and automated ventilator-synchronized IAPV and ERCC were associated with improved ventilation. Their potential role in managing hypercapnic respiratory failure-such as in weaning failure, obstructive lung disease, or neuromuscular weakness-remains a subject for future clinical research. German Registry of Clinical Trials (DRKS00027397).
Authors
- Denis Witham
- Philipp Enghard (ORCID: https://orcid.org/0000-0002-7254-3931)
- Mareen Pigorsch (ORCID: https://orcid.org/0000-0001-5616-7748)
- Julius Valentin Kunz (ORCID: https://orcid.org/0009-0007-8884-3879)
- Roland Körner
- Paul Uwe Thamsen (ORCID: https://orcid.org/0000-0003-0855-617X)
- Julija Peter (ORCID: https://orcid.org/0000-0002-8077-3892)
- Kai‐Uwe Eckardt (ORCID: https://orcid.org/0000-0003-3823-0920)
- A. Krebs
- Karoline Brückner
Institutions
- Humboldt-Universität zu Berlin (DE)
- Engineering Acoustics (United States) (US)
- MSB Medical School Berlin (DE)
- German Society of Medical Intensive Care and Emergency Medicine (DE)
- Technische Universität Berlin (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1371/journal.pone.0333579
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00