The association between serum lipid levels and colorectal cancer risk: A dose-response meta-analysis of 23 studies

Higher TG level was significantly associated with increased risk of CRC and showed a borderline association with colon cancer (HR 1.23, 95% CI 0.99-1.55; p = 0.0576), while TC, HDL, and LDL showed no significant associations with these cancers. For rectum cancer, higher TC was significantly linked to increased risk, whereas TG, HDL, and LDL showed no significant associations. Future research should prioritize longitudinal studies to investigate the mechanistic roles of hormones and the gut microbiota in modulating colorectal cancer risk, alongside multi-omics studies that integrate lipid metabolism with other biological variables such as inflammatory markers and genetic predispositions. These efforts could clarify causal pathways and inform targeted prevention strategies.

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Journal
PLoS ONE
Published
2025-10-16
DOI
https://doi.org/10.1371/journal.pone.0333907
Citations
1
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
Field-Weighted Citation Impact
0.94
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article

The association between serum lipid levels and colorectal cancer risk: A dose-response meta-analysis of 23 studies

Behina Salarian, Hossein Soltaninejad, Zahra Rastad, M Anami Alamdari et al.
1 citations
PLoS ONE
Cancer, Lipids, and Metabolism
0.94
article

The association between serum lipid levels and colorectal cancer risk: A dose-response meta-analysis of 23 studies

Behina Salarian, Hossein Soltaninejad, Zahra Rastad, M Anami Alamdari, Zahra Esmaili, Mina Pourhabib Mamaghani, Iman Elahi Vahed, Mohammad Rahmanian, Shohreh Farshid, Zahra Azimizadeh, Hoda Radmard
article en
1 citations

Abstract

Higher TG level was significantly associated with increased risk of CRC and showed a borderline association with colon cancer (HR 1.23, 95% CI 0.99-1.55; p = 0.0576), while TC, HDL, and LDL showed no significant associations with these cancers. For rectum cancer, higher TC was significantly linked to increased risk, whereas TG, HDL, and LDL showed no significant associations. Future research should prioritize longitudinal studies to investigate the mechanistic roles of hormones and the gut microbiota in modulating colorectal cancer risk, alongside multi-omics studies that integrate lipid metabolism with other biological variables such as inflammatory markers and genetic predispositions. These efforts could clarify causal pathways and inform targeted prevention strategies.

PLoS ONEVol. 20(10)
Tarbiat Modares University (IR), Mashhad University of Medical Sciences (IR), Shiraz University of Medical Sciences (IR), Shahid Sadoughi University of Medical Sciences and Health Services (IR), Islamic Azad University Medical Branch of Tehran (IR), Zahedan University of Medical Sciences (IR), Shahid Beheshti University of Medical Sciences (IR), Xi'an Jiaotong University (CN), University of Gothenburg (SE), Birjand University of Medical Sciences (IR)
Openalex Percentile: Top 19%
Cancer, Lipids, and Metabolism
0.94
DOIOpen Access PDFOpenAlex
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The association between serum lipid levels and colorectal cancer risk: A dose-response meta-analysis of 23 studies — Behina Salarian, Hossein Soltaninejad, et al. · PLoS ONE (2025) | TGRS Research Map | TGRS