Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study
Synaptic dysfunction markers at baseline influence the longitudinal dynamics of CSF sTREM2 independently of AD-pathology related biomarkers throughout aging and earliest stages of neurodegeneration. In turn, higher baseline sTREM2 is associated with more stable neurogranin levels over time. These results suggest an independent interaction between synaptic dysfunction and TREM2-dependent microglial activation throughout aging and early neurodegeneration beyond AD pathology.
Authors
- Barbara B. Bendlin (ORCID: https://orcid.org/0000-0002-0580-9875)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Alberto Villarejo‐Galende (ORCID: https://orcid.org/0000-0002-6834-7620)
- Mariana I. Muñoz-García (ORCID: https://orcid.org/0000-0002-0468-9015)
- David A. Pérez-Martínez (ORCID: https://orcid.org/0000-0001-5587-0415)
- Estrella Morenas‐Rodríguez (ORCID: https://orcid.org/0000-0002-7591-6051)
- Yuetiva Deming
- Gwendlyn Kollmorgen
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Cynthia M. Carlsson (ORCID: https://orcid.org/0000-0001-5743-1563)
- Clara Quijano‐Rubio (ORCID: https://orcid.org/0000-0001-9050-3282)
- Ozioma C. Okonkwo (ORCID: https://orcid.org/0009-0009-8764-811X)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Ferran Lugo-Hernández
Institutions
- Roche (Switzerland) (CH)
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Research Institute Hospital 12 de Octubre (ES)
- Roche Pharma AG (Germany) (DE)
- Hospital Universitario 12 De Octubre (ES)
- Pasqual Maragall Foundation (ES)
- UK Dementia Research Institute (GB)
- Hospital Del Mar (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Indian Institute of Science Bangalore (IN)
- University of Gothenburg (SE)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1186/s13024-025-00901-5
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68