Sepsis in the absence of fever: Determining the criteria for and feasibility of future therapeutic temperature management trials
Fever deficits were large, particularly when the initial body temperature was not febrile. Only 1 in 15 ICU patients with sepsis had an initial body temperature ≥38.3°C. Approximately 2000 adults a year with sepsis and an initial body temperature <37.5°C would potentially be eligible for a trial of therapeutic hyperthermia in our 12 ICUs.
Authors
- Kevin B. Laupland (ORCID: https://orcid.org/0000-0002-1205-5354)
- Ashwin Subramaniam (ORCID: https://orcid.org/0000-0002-8292-7357)
- Alexis Tabah (ORCID: https://orcid.org/0000-0003-3513-2778)
- Chloe Edwards (ORCID: https://orcid.org/0000-0002-6499-5305)
- Peter Garrett (ORCID: https://orcid.org/0000-0002-6562-5349)
- Stephanie V. Blank (ORCID: https://orcid.org/0000-0002-5333-9484)
- Maneesha Tol
- Paul J. Young (ORCID: https://orcid.org/0000-0002-5608-8887)
- Prashanti Marella
- Stephen Luke
- Manoj Saxena (ORCID: https://orcid.org/0000-0002-9368-4194)
- Karthik Venkatesh (ORCID: https://orcid.org/0000-0002-2606-9140)
- Julieann Coombes (ORCID: https://orcid.org/0000-0001-7212-8693)
- Antony George Attokaran (ORCID: https://orcid.org/0000-0001-6208-5116)
- James McCullough
- Sananta Dash (ORCID: https://orcid.org/0000-0003-4282-8386)
- Kyle White (ORCID: https://orcid.org/0000-0002-0129-8297)
- Brian Crichton
- Aashish Kumar (ORCID: https://orcid.org/0009-0001-1494-4550)
Institutions
- Griffith University (AU)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Royal Brisbane and Women's Hospital (AU)
- Epworth Hospital (AU)
- Queen Elizabeth II Jubilee Hospital (AU)
- Gold Coast Hospital (AU)
- Mackay Base Hospital (AU)
- Townsville Hospital (AU)
- Cairns Hospital (AU)
- Logan Hospital (AU)
- Wellington Hospital (NZ)
- Princess Alexandra Hospital (AU)
- UNSW Sydney (AU)
- Australian and New Zealand Intensive Care Society (AU)
- Sunshine Coast University Hospital (AU)
- The George Institute for Global Health (AU)
- Monash Health (AU)
- St George Hospital (AU)
- Prince Charles Hospital (AU)
- Medical Research Institute of New Zealand (NZ)
- Dandenong Hospital (AU)
- Redcliffe Hospital (AU)
- Monash University (AU)
- James Cook University (AU)
Publication Details
- Journal
- Critical Care and Resuscitation
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1016/j.ccrj.2025.100135
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35