Synthesis, In Vitro Antibacterial and Antifungal Evaluations of O,O-Dialkyl(1-hydroxy-1-(4-nitrophenyl)ethyl)phosphonates
In this study, a series of new O,O-dialkyl(1-hydroxy-1-(4-nitrophenyl)ethyl)phosphonates containing various substituents on the phosphorus atom were designed. All synthesized compounds demonstrated antibacterial and antifungal activity against gram-positive bacterial strains B. cereus and S. aureus. It was found that compounds 2–5 exhibit antifungal activity comparable to the control compound Naftifine hydrochloride.
Authors
- А. В. Герасимов (ORCID: https://orcid.org/0000-0003-4213-9724)
- О. К. Поздеев (ORCID: https://orcid.org/0000-0002-6855-3387)
- Kamil Ivshin (ORCID: https://orcid.org/0000-0002-9720-7977)
- R. R. Davletshin (ORCID: https://orcid.org/0000-0002-1708-6985)
- A. N. Sedov (ORCID: https://orcid.org/0000-0002-5094-7783)
- N. V. Davletshina (ORCID: https://orcid.org/0000-0003-0231-337X)
- Polina Kuryntseva (ORCID: https://orcid.org/0000-0002-9274-7077)
- Marina P. Shulaeva (ORCID: https://orcid.org/0000-0003-2152-2126)
- Sofia V. Mosunova
Institutions
- Kazan Federal University (RU)
- Kazan State Medical Academy (RU)
- A.E. Arbuzov Institute of Organic and Physical Chemistry (RU)
Publication Details
- Journal
- Russian Journal of Applied Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1134/s1070427225050027
- Primary Topic
- Organophosphorus compounds synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00