Safety and effectiveness of left atrial appendage occlusion in patients with atrial fibrillation and high bleeding risk: a cardinality-matched comparison with direct oral anticoagulation on long-term stroke and bleeding rates
In this high bleeding risk population, LAAO was associated with similar effectiveness in preventing atrial fibrillation-related stroke and cardiovascular death and significantly lower rates of major bleeding compared to DOAC therapy. This strengthens the value of LAAO as an alternative stroke prevention strategy for patients at high risk of bleeding.
Authors
- Christian Templin (ORCID: https://orcid.org/0000-0003-0287-4193)
- Ronald K. Binder (ORCID: https://orcid.org/0000-0001-9985-3748)
- Philipp Krisai (ORCID: https://orcid.org/0000-0002-4367-2363)
- Peter Ammann (ORCID: https://orcid.org/0000-0002-2410-9807)
- Frank Thomas Ruschitzka (ORCID: https://orcid.org/0000-0001-5972-0596)
- Jürg H. Beer (ORCID: https://orcid.org/0000-0002-7199-0406)
- Nicolas Rodondi (ORCID: https://orcid.org/0000-0001-9083-6896)
- Giorgio Moschovitis (ORCID: https://orcid.org/0000-0002-4043-8061)
- Alexander Gotschy (ORCID: https://orcid.org/0000-0001-8655-3244)
- Davide Di Vece (ORCID: https://orcid.org/0009-0006-4116-3596)
- Elia Rigamonti (ORCID: https://orcid.org/0000-0002-8726-6244)
- Stefan Osswald (ORCID: https://orcid.org/0000-0002-9240-6731)
- Victor Schweiger (ORCID: https://orcid.org/0009-0008-9361-8817)
- Chen Mi (ORCID: https://orcid.org/0000-0003-3265-4618)
- Michael Kühne (ORCID: https://orcid.org/0000-0002-2937-3711)
- Philipp Jakob (ORCID: https://orcid.org/0000-0002-2443-6090)
- David Conen (ORCID: https://orcid.org/0000-0002-2459-5251)
- Thomas Gilhofer (ORCID: https://orcid.org/0000-0002-1708-156X)
- Leo Hermann Bonati (ORCID: https://orcid.org/0000-0003-1163-8133)
- Julia Stehli (ORCID: https://orcid.org/0000-0003-3089-1062)
- Jonathan Michel (ORCID: https://orcid.org/0000-0003-3253-9687)
- Albert Markus Kasel (ORCID: https://orcid.org/0000-0002-1090-9213)
- Moa Lina Haller (ORCID: https://orcid.org/0009-0006-2380-349X)
- Alessandro Candreva (ORCID: https://orcid.org/0000-0002-6676-7541)
- Tobias Reichlin (ORCID: https://orcid.org/0000-0002-7197-8415)
- Linn Ryberg
- Victoria Bokemeyer
- Mario Gehler
- Fabian Nietlispach
- Stefanie Aeschbacher (ORCID: https://orcid.org/0000-0001-8134-2421)
- Barbara E. Stähli
Institutions
- University of Bern (CH)
- University of Basel (CH)
- ZHAW Zurich University of Applied Sciences (CH)
- University of Zurich (CH)
- University of St.Gallen (CH)
- Universitätsmedizin Greifswald (DE)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Population Health Research Institute (CA)
- Institute for Biomedical Engineering (CH)
- Ente Ospedaliero Cantonale (CH)
- Kantonsspital Winterthur (CH)
- University Hospital of Zurich (CH)
- Deutsches Herzzentrum der Charité (DE)
- Klinikum Wels-Grieskirchen (AT)
- Kantonsspital Baden (CH)
- Reha Rheinfelden (CH)
- Spital Zollikerberg (CH)
Publication Details
- Journal
- Swiss Medical Weekly
- Published
- 2025-10-15
- DOI
- https://doi.org/10.57187/s.4288
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00