Plasma <i>N</i> -Glycan Profiling Enhances Diagnostic Precision in Multiple Sclerosis, AQP4-Ab NMOSD, and MOGAD
These findings underscore the potential of plasma <i>N</i>-glycomics as a diagnostic tool for neuroinflammatory diseases. While further research is needed to clarify the mechanistic links between glycomic alterations and disease pathology, our results suggest that plasma <i>N</i>-glycan profiling could improve disease classification. Given its noninvasive and cost-effective nature, this approach holds promise as a complementary diagnostic tool for CNS demyelinating diseases in clinical practice.
Authors
- Daniel I. R. Spencer (ORCID: https://orcid.org/0000-0001-6386-0890)
- Paulina A. Urbanowicz (ORCID: https://orcid.org/0000-0003-4158-0462)
- Wenzheng Xiong (ORCID: https://orcid.org/0000-0001-5713-7305)
- Gabriele Carmine DeLuca (ORCID: https://orcid.org/0000-0003-0342-5197)
- Daniel C. Anthony (ORCID: https://orcid.org/0000-0003-1380-6655)
- Mark R. Woodhall (ORCID: https://orcid.org/0009-0008-5980-7462)
- Patrick Joseph Waters (ORCID: https://orcid.org/0000-0003-4142-2667)
- Maria Isabel Leite (ORCID: https://orcid.org/0000-0002-4277-9855)
- Jack Cheeseman (ORCID: https://orcid.org/0000-0003-1112-217X)
- Tereza Kačerová (ORCID: https://orcid.org/0000-0002-9477-0182)
- Fay Probert (ORCID: https://orcid.org/0000-0002-8580-2023)
- Tianrong Yeo (ORCID: https://orcid.org/0000-0002-3648-0953)
- Thomas Sénard (ORCID: https://orcid.org/0000-0001-5951-4127)
- Megan Sealey
- James S. O. McCullagh (ORCID: https://orcid.org/0000-0003-4733-1205)
- Georgia Elgood-Hunt
- Jacqueline A. Palace (ORCID: https://orcid.org/0000-0003-4779-6133)
- Luisa Saldana
Institutions
- Nanyang Technological University (SG)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Culham Science Centre (GB)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda USL di Bologna (IT)
- Duke-NUS Medical School (SG)
- National Neuroscience Institute (SG)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1212/nxi.0000000000200502
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47