Neural correlates underlying high-frequency stimulation-induced secondary hyperalgesia in humans
Neural correlates of HFS-induced CS are consistent with other experimental CS models such as capsaicin, particularly increased activity of the nucleus cuneiformis - a nucleus of the descending pain modulatory system implicated in human and animal models of CS. Furthermore, changes in functional connectivity between brain regions involved in descending pain modulation suggest a shift toward facilitation over inhibition.
Authors
- André Mouraux (ORCID: https://orcid.org/0000-0003-1056-5980)
- Rolf‐Detlef Treede (ORCID: https://orcid.org/0000-0001-8065-1708)
- Irene Tracey (ORCID: https://orcid.org/0000-0003-4134-6115)
- Nanna Brix Finnerup (ORCID: https://orcid.org/0000-0001-5541-0240)
- Richard Rogers (ORCID: https://orcid.org/0000-0002-5178-4920)
- Ombretta Caspani (ORCID: https://orcid.org/0000-0002-9700-3149)
- Francesca Fardo (ORCID: https://orcid.org/0000-0002-9974-6261)
- Sophie Clarke (ORCID: https://orcid.org/0000-0001-6464-5578)
- Vishvarani Wanigasekera (ORCID: https://orcid.org/0000-0001-9922-8993)
Institutions
- Aarhus University (DK)
- Heidelberg University (DE)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Bernstein Center for Computational Neuroscience Heidelberg-Mannheim (DE)
- Danish Pain Research Center (DK)
- UCLouvain (BE)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1097/pr9.0000000000001342
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00