δ-Cells Control a Subset of β-Cells in Mouse Pancreatic Islets
Optical activation or δ-cells stimulate somatostatin secretion. δ-Cell depolarization evokes β-cell action potential firing and insulin release. δ-Cell activation results in islet-wide synchronized β-cell cytoplasmic free Ca2+ concentration increases. δ-Cell inhibition aborts cytoplasmic free Ca2+ concentration oscillations in β-cell neighbors.
Authors
- Caroline Miranda (ORCID: https://orcid.org/0000-0002-4649-2093)
- Thomas G. Hill (ORCID: https://orcid.org/0000-0002-4637-3879)
- Cristiano Santos (ORCID: https://orcid.org/0000-0002-9972-5583)
- Lakshmi Kothegala (ORCID: https://orcid.org/0000-0002-6938-620X)
- Quan Zhang (ORCID: https://orcid.org/0000-0002-3626-4855)
- Andrei I. Tarasov (ORCID: https://orcid.org/0000-0002-8883-176X)
- Rui Gao (ORCID: https://orcid.org/0000-0002-0845-1370)
- Johan Tolö (ORCID: https://orcid.org/0000-0001-9648-4721)
- Patrik Rorsman (ORCID: https://orcid.org/0000-0001-7578-0767)
- Haiqiang Dou (ORCID: https://orcid.org/0000-0002-1551-4114)
Institutions
- University of Ulster (GB)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- University of Coimbra (PT)
- University of Gothenburg (SE)
Publication Details
- Journal
- Diabetes
- Published
- 2025-10-16
- DOI
- https://doi.org/10.2337/db25-0302
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01