Children born small-for-gestational-age exhibit normal body fat but elevated hs-CRP and hepatocellular lipid content
Prepubertal children born small-for-gestational-age (SGA), although still shorter and leaner than their peers, exhibit elevated liver triglyceride concentrations on proton MR spectroscopy associated with elevated hs-CRP levels. Elevated hs-CRP and liver triglyceride concentrations can be early indicators of pathological metabolic changes associated with later cardiometabolic abnormalities.
Authors
- Juhana Hakumäki (ORCID: https://orcid.org/0000-0001-7341-5440)
- Leena Hintikka
- Reima Palonen
- Jarmo Jääskeläinen (ORCID: https://orcid.org/0000-0003-0189-6323)
- Henrikki Nordman
- Hanna Huopio
- Raimo Voutilainen (ORCID: https://orcid.org/0000-0002-7858-665X)
- Tomi Laitinen
Institutions
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1038/s41390-025-04464-5
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Itä-Suomen Yliopisto
- Suomen Kulttuurirahasto
- Kuopion Yliopistollinen Sairaala
- Northern Savo Hospital District