CAA-derived IL-6 promoted the PD-L1 expression of breast cancer via STAT3/miR-497a-5p signaling
Our study demonstrated that CAAs promoted the malignant behaviors of BC and enhanced immunosuppression in TME. Specifically, CAA-derived IL-6 promoted the PD-L1 expression of BC via STAT3/miR-497a-5p signaling, thereby contributing to BC progression.
Authors
- Chongru Zhao
- Xiaomei Zhou (ORCID: https://orcid.org/0000-0002-1264-0553)
- Xing Li (ORCID: https://orcid.org/0000-0002-0742-1364)
- Qi Zhang (ORCID: https://orcid.org/0000-0003-0564-9215)
- Gezi Li
- Jun Zhang (ORCID: https://orcid.org/0000-0002-3067-2620)
Institutions
- Guangzhou Development Zone Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1007/s00432-025-06324-5
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology