Alternative pathway–mediated tubular complement activation in human proteinuric kidney diseases: a proof-of-concept study
Apical tubular complement activation in proteinuric patients is mainly via the alternative pathway, potentially initiated by properdin binding to syndecan-1. Inhibition of alternative pathway tubular complement activation may therefore be beneficial for patients with proteinuria.
Authors
- Marius C. van den Heuvel (ORCID: https://orcid.org/0000-0001-6985-7107)
- Firas Farisi Alkaff (ORCID: https://orcid.org/0000-0002-5628-1345)
- Stefan P. Berger (ORCID: https://orcid.org/0000-0003-2228-4676)
- Mohamed R. Daha (ORCID: https://orcid.org/0000-0002-0113-0750)
- Rosa Lammerts (ORCID: https://orcid.org/0000-0002-9970-9006)
- Ingeborg M. Bajema
- Gesa Tiller (ORCID: https://orcid.org/0000-0002-6076-2256)
- Jacob van den Born
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Universitas Airlangga (ID)
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/ckj/sfaf320
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Universitair Medisch Centrum Groningen
- Universitas Airlangga