How many NOTCHes (activation pathways) are there in CLL?
In this issue of Blood, Guo et al 1 describe a novel mechanism of NOTCH1 pathway activation, involving the most frequent 3' untranslated region (UTR) mutation (g.139390152, A>G), corresponding to a A>G mutation occurring 371 nucleotides downstream of the 7668 nucleotide-long NOTCH1 coding sequence.
Authors
- Federico Pozzo (ORCID: https://orcid.org/0000-0002-2986-7658)
- Valter Gattei (ORCID: https://orcid.org/0000-0001-5933-9680)
Institutions
- Centro di Riferimento Oncologico (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Blood
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1182/blood.2025030461
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00