Mast cells act as pro-angiogenic and pro-tumorigenic players in pituitary gonadotroph tumors
We demonstrate that mast cells represent a new actor of the gonadotroph TME, and highlight their pro-angiogenic and pro-tumorigenic roles as potential targets for the therapeutic treatment of gonadotroph tumors.
Authors
- Marie Chanal (ORCID: https://orcid.org/0000-0001-8069-8821)
- Mirela Diana Ilie (ORCID: https://orcid.org/0000-0001-7248-7258)
- Alexandre Vasiljevic (ORCID: https://orcid.org/0000-0001-5954-0317)
- Maxime Lepetit
- Philippe Bertolino (ORCID: https://orcid.org/0000-0001-8064-8269)
- Emmanuel Jouanneau
- Gérald Raverot (ORCID: https://orcid.org/0000-0002-9517-338X)
- David Bernard (ORCID: https://orcid.org/0000-0002-1557-2074)
- Franck Picard (ORCID: https://orcid.org/0000-0001-8084-5481)
- Laura Chinezu (ORCID: https://orcid.org/0000-0003-3013-490X)
- Álvaro Flores‐Martínez (ORCID: https://orcid.org/0000-0002-4926-3288)
- Olivier Gandrillon (ORCID: https://orcid.org/0000-0002-3676-6513)
- Benoît Samson
- Ayoub Lehiani
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut national de recherche en sciences et technologies du numérique (FR)
- Inserm (FR)
- Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO)
- Hospices Civils de Lyon (FR)
- Centre Inria de l'Université Grenoble Alpes (FR)
- Institutul Național de Endocrinologie C.I. Parhon (RO)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Spitalul Clinic Judetean de Urgenta Târgu Mureş (RO)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/neuonc/noaf241
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Fondation ARC pour la Recherche sur le Cancer
- Ligue Contre le Cancer
- École Normale Supérieure de Lyon