Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest

This study aimed to investigate cervical vessel hemodynamics during 7 days of -6° head-down tilt (HDT) bed rest (BR) and 5 days of recovery in 40 healthy males, focusing on bilateral analysis and dynamic temporal monitoring. Diameter, flow velocity, and blood flow volume (BFV) of bilateral common (CCAs), internal (ICAs), external carotid arteries and vertebral arteries (VAs) were measured at eight time points using ultrasound. Cervical vessels exhibited heterogeneous and lateralized responses. Left VA exhibited the most pronounced BFV and velocity fluctuations, with significant reductions during HDT and recovery to baseline post-HDT, while right VA remained stable. CCAs and ICAs had dynamic diameter and velocity changes, but stable BFVs. Left VA BFV reduction was significantly associated with right VA dominance, elevated heart rate, and increased mean arterial pressure at HDT 3 d. Despite stable total BFV, left VA BFV declined during BR, warranting further monitoring.

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Publication Details

Journal
npj Microgravity
Published
2025-10-16
DOI
https://doi.org/10.1038/s41526-025-00524-6
Primary Topic
Spaceflight effects on biology
Type
article
Field-Weighted Citation Impact
0.00

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article

Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest

Linxue Qian, Fengxia Yu, Peng‐Gang Qiao, Zixu Huang et al.
npj Microgravity
Spaceflight effects on biology
article

Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bed rest

Linxue Qian, Fengxia Yu, Peng‐Gang Qiao, Zixu Huang, Pengling Ren, Zhenchang Wang, Ruihua Dong, Xia Ma, Yiwen Wang, Rui Wang, Yawen Liu, Jianxiong Zhang, Weitao Zheng
article en

Abstract

This study aimed to investigate cervical vessel hemodynamics during 7 days of -6° head-down tilt (HDT) bed rest (BR) and 5 days of recovery in 40 healthy males, focusing on bilateral analysis and dynamic temporal monitoring. Diameter, flow velocity, and blood flow volume (BFV) of bilateral common (CCAs), internal (ICAs), external carotid arteries and vertebral arteries (VAs) were measured at eight time points using ultrasound. Cervical vessels exhibited heterogeneous and lateralized responses. Left VA exhibited the most pronounced BFV and velocity fluctuations, with significant reductions during HDT and recovery to baseline post-HDT, while right VA remained stable. CCAs and ICAs had dynamic diameter and velocity changes, but stable BFVs. Left VA BFV reduction was significantly associated with right VA dominance, elevated heart rate, and increased mean arterial pressure at HDT 3 d. Despite stable total BFV, left VA BFV declined during BR, warranting further monitoring.

npj MicrogravityVol. 11(1)
Capital Medical University (CN), Chinese Academy of Sciences (CN), National Space Science Center (CN), Beijing Friendship Hospital (CN)
Capital Medical University, Beijing Postdoctoral Science Foundation, Beijing Friendship Hospital, Capital Medical University
Openalex Percentile: Top 63%
Spaceflight effects on biology
DOIOpen Access PDFOpenAlex
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