Quercetin reverses β1-adrenoceptor autoantibody-induced heart failure by promoting MDM2-mediated ubiquitination and degradation of p53 in cardiomyocytes
Quercetin rescues β<sub>1</sub>-AA-impaired cardiomyocyte autophagy by activating MDM2-dependent <i>p53</i> ubiquitination and degradation, thereby attenuating HF progression. These findings establish quercetin as the mechanistic basis of the cardioprotective effects of Qiliqiangxin and provide preclinical evidence for targeting autophagy by regulating <i>p53</i> in β<sub>1</sub>-AA-induced cardiac dysfunction.
Authors
- Li Yang (ORCID: https://orcid.org/0000-0001-7412-9841)
- Yaolin Long
- Xiaoyan Zhi (ORCID: https://orcid.org/0009-0006-3337-1328)
- Mingxia Ma
- Weiqian Liu (ORCID: https://orcid.org/0000-0002-3857-7863)
- Yuan Yuan (ORCID: https://orcid.org/0000-0002-1234-6813)
- Li Wang (ORCID: https://orcid.org/0000-0002-4206-0285)
- Zhijun Zhang
- Xiaohui Wang (ORCID: https://orcid.org/0000-0003-1434-2055)
- Jin Xue (ORCID: https://orcid.org/0000-0002-5527-8638)
- Xiawei Jiang (ORCID: https://orcid.org/0000-0002-4128-4914)
- Jiayan Feng
Institutions
- Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fnut.2025.1674507
- Primary Topic
- Tea Polyphenols and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00