Utility of a Multimodal Biomarker Panel and Serum Proapoptotic Activity to Refine Diagnosis of Ovarian Adnexal Masses
The evaluation of CA125, HE4, MRP8/14, and apoptosis (Classifier 1) and, more prominently, the measurement of additional molecules: OPN, SAA, IL-6, IL-8, and IGFBP-4 (Classifier 2), systematically outperformed the ROMA. Both achieved superior specificity and balanced accuracy (Youden's J index) across all clinical comparisons by capturing the biological diversity of malignancies.
Authors
- Rodolfo Hernández‐Gutiérrez (ORCID: https://orcid.org/0000-0001-7566-6825)
- Jesús García-Gómez (ORCID: https://orcid.org/0000-0003-3288-355X)
- Luis Felipe Jave‐Suárez (ORCID: https://orcid.org/0000-0001-6209-5031)
- Andrea Molina-Pineda (ORCID: https://orcid.org/0000-0002-8313-1932)
- Adriana Aguilar‐Lemarroy (ORCID: https://orcid.org/0000-0001-9288-4824)
- Sayma Vizcarra-Ramos (ORCID: https://orcid.org/0000-0001-9967-8732)
- Raquel Villegas-Pacheco
- Francisco Osiel Jauregui-Salazar
- Aleyda Guadalupe Zamudio-Martínez
- Benjamín González-Amézquita
- Lizeth Montserrat Aguilar-Vazquez
Institutions
- Mexican Social Security Institute (MX)
- Universidad Autónoma de Sinaloa (MX)
- Secretaría de Salud de Jalisco (MX)
- Centro de Investigación y Proyectos en Ambiente y Desarrollo (MX)
Publication Details
- Journal
- Diseases
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3390/diseases13100342
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Mexicano del Seguro Social