Treatment intervals with first-generation anti-vascular endothelial growth factor drugs: evaluating the unmet need in a real-world neovascular age-related macular degeneration national database
Despite receiving a number of injections within a TAE range, a substantial proportion of eyes failed to achieve extended treatment intervals at 12 and 24 months (61.8% and 52.9%, respectively). These results underscore the significant unmet therapeutic need in the management of nAMD with currently approved first-generation anti-VEGF agents.
Authors
- Gonzaga Garay‐Aramburu (ORCID: https://orcid.org/0000-0001-5255-8426)
- Carolina Arruabarrena (ORCID: https://orcid.org/0000-0002-5312-8900)
- Laura Sararols-Ramsay
- Pilar Calvo (ORCID: https://orcid.org/0000-0002-6202-2382)
- Miguel Ángel Zapata (ORCID: https://orcid.org/0000-0002-0096-4569)
- Javier Zarranz‐Ventura (ORCID: https://orcid.org/0000-0003-2338-8143)
- Pablo Arnáiz
- Paula García-Lunar
Institutions
- Universidade da Coruña (ES)
- University of the Basque Country (ES)
- Hospital Universitario La Paz (ES)
- Bellvitge University Hospital (ES)
- Hospital Costa del Sol (ES)
- Clínica Rementería (ES)
- Hospital de Nens de Barcelona (ES)
- Hospital de Basurto (ES)
- Hospital de La Ribera (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Ajuntament de L’Hospitalet (ES)
- Hospital Universitario Príncipe de Asturias (ES)
- Hospital Universitario Araba (ES)
- IVI Valencia Clinic (ES)
- Hospital General de Granollers (ES)
- Hospital Universitario Miguel Servet (ES)
- Hospital Clínic de Barcelona (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Del Mar (ES)
- Hospital de Sant Joan Despí Moisès Broggi (ES)
- Clinica Universidad de Navarra (ES)
- Hospital Clínico Universitario Lozano Blesa (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
- Hospital de Cruces (ES)
- Hospital Universitario del Vinalopó (ES)
- Hospital Quirón Torrevieja (ES)
- IVI Sevilla Clinic (ES)
- Roche (Spain) (ES)
- Hospital Universitario del Henares (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Complejo Hospitalario de Pontevedra (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Hospital Provincial de Conxo (ES)
- Universitat de Barcelona (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Eye
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1038/s41433-025-03996-8
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41