High PEEP Activates ITGB1, Inducing Diaphragm Fibrosis During Prolonged Mechanical Ventilation
ITGB1 mediates PEEP-induced diaphragm fibrosis via TGFβ-1 signaling and collagen deposition, suggesting ITGB1 targeting as a potential therapeutic strategy for VIDD. These findings elucidate the mechanotransduction mechanisms underlying MV-associated diaphragm dysfunction.
Authors
- Peifeng Xu (ORCID: https://orcid.org/0000-0002-3353-9972)
- Ye Jiang (ORCID: https://orcid.org/0000-0002-6683-0205)
- Xiaolan Yu (ORCID: https://orcid.org/0000-0003-1588-9693)
- Jiahong Gong
- Ying Xu (ORCID: https://orcid.org/0000-0002-6689-7768)
- Rui He (ORCID: https://orcid.org/0000-0001-5288-9786)
- Huiqing Ge (ORCID: https://orcid.org/0000-0002-5822-2998)
- Weimin Shen
- Jianwei Jia (ORCID: https://orcid.org/0000-0002-6510-4201)
- Xiaoli Qian
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3390/biom15101466
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00