A novel psychedelic 5-HT <sub>2A</sub> receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer
These PD findings were similar in nature and magnitude to other 5-HT<sub>2A</sub> receptor agonists that have been studied clinically. In line with the GM-2505 PK profile, the duration of cardiovascular and subjective effects was shorter than psilocybin but longer than DMT, demonstrating a potentially more practical temporal profile for use in a supervised clinical setting compared to longer-acting 5-HT<sub>2A</sub> receptor agonists, with an optimal dose range of 10-15 mg IV. Clinical trial (ISRCTN64428072) registration: https://www.isrctn.com/ISRCTN64428072.
Authors
- Gerard J. Marek (ORCID: https://orcid.org/0000-0001-8103-4306)
- Eric W. Austin (ORCID: https://orcid.org/0009-0005-0179-2219)
- Shane Raines (ORCID: https://orcid.org/0009-0007-0637-8476)
- Adam K. Klein (ORCID: https://orcid.org/0000-0002-1640-9324)
- Zoë A. Hughes (ORCID: https://orcid.org/0000-0001-7174-0944)
- Wai Yie Leong (ORCID: https://orcid.org/0000-0002-5389-1121)
- Soma Makai‐Bölöni (ORCID: https://orcid.org/0000-0002-5971-381X)
- Daniel Umbricht (ORCID: https://orcid.org/0000-0003-0272-2157)
- Marije E. Otto (ORCID: https://orcid.org/0000-0002-5767-604X)
- Jonathan Sporn
- Laura Borghans (ORCID: https://orcid.org/0000-0001-5580-1153)
- Maria Joanna Juachon (ORCID: https://orcid.org/0009-0002-8064-2013)
- Andrew C. Kruegel (ORCID: https://orcid.org/0000-0002-9156-8755)
- Dino Dvořák (ORCID: https://orcid.org/0000-0003-3884-1393)
- Jason Winters
- Fas J. Krol (ORCID: https://orcid.org/0000-0002-1880-044X)
- Gabriël E. Jacobs (ORCID: https://orcid.org/0000-0002-5140-9450)
- Edward P. Christian
- Anne J. van der Graaf
Institutions
- Leiden University (NL)
- Leiden University Medical Center (NL)
- Centre for Human Drug Research (NL)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1177/02698811251378512
- Citations
- 1
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.31