Free water, perivascular spaces, and diffusivity along perivascular spaces dynamics after recent small subcortical infarcts and their associations with cognition
Our findings demonstrate RSSIs are associated with disrupted MRI-derived proxies of brain fluid dynamics, characterized by increased ISF and PVS dysfunction in the ipsilesional hemisphere. Baseline PVS volume is correlated with cognitive changes in RSSI patients, highlighting the potential of early PVS-targeted interventions to prevent post-stroke cognitive impairment.
Authors
- Peiyu Huang (ORCID: https://orcid.org/0000-0003-4226-9369)
- Xiao Luo (ORCID: https://orcid.org/0000-0003-1743-7842)
- Fuzhou Li (ORCID: https://orcid.org/0000-0002-1731-1142)
- Hui Hong (ORCID: https://orcid.org/0000-0002-8807-7859)
- Yuan Xu (ORCID: https://orcid.org/0000-0003-2100-9437)
- Lige Zhang (ORCID: https://orcid.org/0009-0002-3845-0413)
- Shouping Dai
- Xiaopei Xu (ORCID: https://orcid.org/0000-0002-0342-383X)
- Yanyan Wang (ORCID: https://orcid.org/0000-0002-6231-5011)
- Tiantian Qiu
Institutions
- Linyi People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1177/17474930251390996
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36