FeS/CeO <sub>2</sub> /Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic‐H <sub>2</sub> S and ultrasound modulated nanozyme as well as osteogenesis
Abstract The treatment of infectious arthritis faces multiple challenges, including the exacerbation of traditional antibiotic resistance and the difficulty of regulating the tissue microenvironment. In this study, the FeS/CeO 2 /Cur (curcumin) heterostructure was constructed through interface engineering, and an ultrasonic (US) responsive nanotherapeutic platform was proposed, which combined sonodynamic‐H 2 S antibacterial action with US modulated nanozyme activity. FeS/CeO 2 /Cur integrated the intrinsic redox properties of Ce 3+ /Ce 4+ with the piezoelectric catalytic effect. Under US irradiation, FeS/CeO 2 /Cur nanozyme exhibited an interface‐enhanced piezoelectric effect. It generated ·O 2 − and · 1 O 2 radicals through piezoelectric catalytic activity, while achieving the US‐responsive release of H2S. The Ce 3+ /Ce 4+ dynamic equilibrium system triggered shows US modulated antioxidant properties, which can scavenge pathogenic ROS by Ce 3+ /Ce 4+ redox cycling during the interface. FeS/CeO 2 /Cur's sonodynamic antibacterial activity revealed that it achieved broad‐spectrum sterilization by disrupting bacterial ATP metabolism and regulating related genes, including narG , purM , and narJ . The in vivo bacterial arthritis model also confirmed that FeS/CeO 2 /Cur can eliminate bacteria rapidly and promote osteogenic differentiation, providing an effective treatment strategy for infectious arthritis.
Authors
- Li Liang (ORCID: https://orcid.org/0000-0001-5918-2003)
- Yuan Li (ORCID: https://orcid.org/0000-0001-9507-3007)
- Hongbo Wu (ORCID: https://orcid.org/0000-0001-6323-8401)
- Allan Z. Zhao (ORCID: https://orcid.org/0000-0002-2492-0923)
- Rui Huang (ORCID: https://orcid.org/0000-0002-3343-066X)
- Jianjun Yan (ORCID: https://orcid.org/0000-0002-3546-6412)
- Tao Huang (ORCID: https://orcid.org/0000-0003-4153-3607)
- Ronghao Zhang
- Yulin Lin (ORCID: https://orcid.org/0000-0001-5574-7062)
- H Z Li (ORCID: https://orcid.org/0000-0002-9190-9492)
- Zhi‐Gang Chen (ORCID: https://orcid.org/0000-0002-9309-7993)
- Yan Li (ORCID: https://orcid.org/0000-0002-1612-5719)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-8194-6057)
- Yu Huang (ORCID: https://orcid.org/0009-0003-4802-3017)
- Lei Tan (ORCID: https://orcid.org/0000-0002-9974-7766)
- Jinlong Fu
- Ju-Ping Xie
Institutions
- City University of Hong Kong (HK)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Rare Metals
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1007/s12598-025-03606-2
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00