Targeting Protein Kinase-α in Breast Cancer: Molecular Docking-Guided Design of 7α-Acetoxy-6β-Hydroxyroyleanone Derivatives
Background and Purpose Plectranthus spp. have been traditionally used to treat various ailments, including cancer. Among their bioactive components, 7α-acetoxy-6β-hydroxyroyleanone 1 and 6,7-dehydroroyleanone 2 showed notable antiproliferative activit
Authors
- Ana Catarina Matos (ORCID: https://orcid.org/0000-0002-5330-1005)
- Patrícia Rijo (ORCID: https://orcid.org/0000-0001-7992-8343)
- Carlos A. M. Afonso (ORCID: https://orcid.org/0000-0002-7284-5948)
- Alfonso T. García‐Sosa (ORCID: https://orcid.org/0000-0003-0542-4446)
- Vera M. S. Isca (ORCID: https://orcid.org/0000-0002-9045-7287)
- Lucı́lia Saraiva (ORCID: https://orcid.org/0000-0002-9531-4939)
- Rita de Fátima da Silva (ORCID: https://orcid.org/0009-0006-9328-8171)
- Daniel J. V. A. dos Santos (ORCID: https://orcid.org/0000-0001-7798-8641)
Institutions
- Institute of the Estonian Language (EE)
- University of Lisbon (PT)
- Rede de Química e Tecnologia (PT)
- Universidade Lusófona (PT)
Publication Details
- Published
- 2025-10-16
- DOI
- https://doi.org/10.22541/au.176061721.16605177/v1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00