Outcomes of patent foramen ovale closure in patients over 60 years with cryptogenic stroke: A systematic review and meta-analysis
Based on available data, which is predominantly derived from observational studies, PFO closure is associated with a reduced risk of recurrent stroke compared to ATA in patients over 60 years. However, these findings are subjected to limitations, including the potential for selection bias, unmeasured confounding, and insufficient long-term follow-up. Furthermore, long-term randomized trials are essential to definitively confirm efficacy and establish clinical guidelines for PFO closure in this older population.
Authors
- Christine S. Zuern (ORCID: https://orcid.org/0000-0001-6625-284X)
- Brett C. Meyer (ORCID: https://orcid.org/0000-0002-2877-1187)
- Sven Poli (ORCID: https://orcid.org/0000-0002-0286-8781)
- Thomas Hemmen
- Dawn Meyer (ORCID: https://orcid.org/0000-0003-3225-1392)
- Kunal Agrawal (ORCID: https://orcid.org/0000-0001-5882-6647)
- Daniela Trabattoni (ORCID: https://orcid.org/0000-0002-6319-4119)
- Ana H. Maleki
- Sherief A. Ghozy (ORCID: https://orcid.org/0000-0001-5629-3023)
- Oana Dumitrașcu (ORCID: https://orcid.org/0000-0002-1031-9184)
- Royya Modir (ORCID: https://orcid.org/0000-0002-4782-0861)
- Reza Bavarsad Shahripour (ORCID: https://orcid.org/0000-0003-4805-529X)
- Seyed Behnam Jazayeri (ORCID: https://orcid.org/0000-0003-2860-6496)
- Soumya Ravichandran (ORCID: https://orcid.org/0009-0008-2370-1965)
- Cattien Phan
Institutions
- Mayo Clinic (US)
- Loma Linda University (US)
- WinnMed (US)
- University of California San Diego (US)
- Centro Cardiologico Monzino (IT)
- Mayo Clinic in Arizona (US)
- Hertie Institute for Clinical Brain Research (DE)
- Mayo Clinic in Florida (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Neurological Surgery (US)
- University of Tübingen (DE)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1177/17474930251392333
- Citations
- 1
- Primary Topic
- Cardiovascular and Diving-Related Complications
- Type
- article
- Field-Weighted Citation Impact
- 1.52