Research progress in techniques related to pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Abstract Pressurized intraperitoneal aerosol chemotherapy is a novel method for intraperitoneal chemotherapy, with favorable feasibility, safety, and tolerability. The preliminary results are encouraging, and numerous clinical researches of this therapy are ongoing. To further optimize drug distribution, penetration depth, and therapeutic efficacy of PIPAC, basic and clinical studies have also been carried out, such as modification of nebulizer, rotational PIPAC, hyperthermic PIPAC, and electrostatic precipitation of PIPAC. In addition to the investigation of chemotherapeutic agents, the potential of non-chemotherapeutic drugs for intraperitoneal aerosolized drug delivery has been examined, including anti-adhesion drugs, nanoparticles, nucleic acid drugs, and oncolytic viruses. This paper offers a comprehensive overview of the technological advancements associated with PIPAC.