An Association Between GLP-1 Receptor Expression on Regulatory T Cells and the Severity of Coronary Artery Stenosis and Inflammatory Dysregulation in Coronary Heart Disease
Reduced Treg frequency and impaired GLP-1R expression on Tregs are independently associated with CHD susceptibility and stenosis progression, potentially mediated by dysregulation of inflammatory cytokines. The GLP-1R pathway in Tregs represents a novel immunomodulatory target for therapeutic intervention in CHD.
Authors
- Hang Qian (ORCID: https://orcid.org/0000-0001-9171-0232)
- Hao Xu (ORCID: https://orcid.org/0000-0003-4444-8408)
- Wenwen Wu (ORCID: https://orcid.org/0000-0002-7465-6606)
- Aihua Mei
- Tony Yao (ORCID: https://orcid.org/0000-0002-8744-3597)
- Xinwen Min (ORCID: https://orcid.org/0000-0002-8429-6560)
- Mengmeng Yue (ORCID: https://orcid.org/0009-0007-5665-2998)
- Long Chen (ORCID: https://orcid.org/0000-0003-1110-6495)
- Jun Chen (ORCID: https://orcid.org/0000-0002-9071-2436)
- Handong Yang (ORCID: https://orcid.org/0000-0003-0550-362X)
- Xiaolei Li (ORCID: https://orcid.org/0000-0003-4913-0028)
- Min Yang (ORCID: https://orcid.org/0000-0001-8119-801X)
- Kun Wu (ORCID: https://orcid.org/0000-0002-4813-5671)
- Ming Lv
Institutions
- Hubei University of Medicine (CN)
- Dongfeng General Hospital (CN)
Publication Details
- Journal
- Reviews in Cardiovascular Medicine
- Published
- 2025-09-25
- DOI
- https://doi.org/10.31083/rcm39927
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hubei University