Endometrial Steroid Receptor Dysregulation and Its Association with Vitamin D, AMH, and Inflammation in Recurrent Implantation Failure: A Case-Control Study.
The study links endometrial PGR-B expression and vitamin D3 levels to decidualization and inflammation regulation. It suggests that infertility in women with RIF may stem from elevated ESR-α, increased inflammation, and reduced <i>ESR-β</i> and PGR-B expression. Further research is needed on <i>PGR-B</i>, <i>VDR</i> gene expression, and fertility biomarkers. ROC analysis indicates that endometrial steroid receptor expression, AMH, and vitamin D3 levels could aid in diagnosing RIF.
Authors
- Rahim Rostami (ORCID: https://orcid.org/0000-0002-5504-6319)
- Azadeh Rezaei (ORCID: https://orcid.org/0000-0003-0907-4447)
- Soudabeh Fallah
- Elmira Mahdinia (ORCID: https://orcid.org/0009-0001-0160-5111)
- Jamileh Jahanbakhsh
- Afsaneh Tehranian (ORCID: https://orcid.org/0000-0001-9119-9593)
- Sahar Yarahmadi (ORCID: https://orcid.org/0000-0002-8171-1650)
- Nafiseh Omodiani
Institutions
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-30
- DOI
- https://doi.org/10.22074/ijfs.2025.2024520.1640
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Iran University of Medical Sciences